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Dr. Johann Weiss: The Truth About Wrinkles They Didn’t Want You to Know

Dr. Johann Weiss is a renowned German dermatologist who worked for over 15 years at the major pharmaceutical company "BioPharm AG."

He was a leading researcher in the field of skin aging and played a key role in developing several popular anti-aging treatments and skincare products.

His work was highly regarded in scientific circles, and he was considered one of the top experts in his field.

However, over the years, Johann began to notice that his research was often suppressed or altered by the company's management.

He discovered that one of the key causes of premature wrinkles might not only be natural aging or sun exposure but also the impact of certain synthetic additives found in popular cosmetic products and even some anti-aging treatments.

According to his findings, these substances disrupted the skin's natural repair processes, leading to a loss of elasticity and the formation of wrinkles.

When Johann tried to raise this issue at internal meetings, he was told that it was "not in the company's best interest."

It turned out that "BioPharm AG" collaborated with major cosmetics and skincare manufacturers, and disclosing this information could harm their profits.

Johann was forced to sign a strict non-disclosure agreement and remained silent for a long time, feeling trapped.

Everything changed in 2023 when Johann decided to resign from the company.

After leaving, he began to speak publicly about his research.

He revealed that many popular anti-aging products contain ingredients that only temporarily plump the skin or reduce the appearance of wrinkles without addressing the root cause—and sometimes even accelerate skin aging.

He also explained that synthetic substances like parabens, sulfates, and certain types of alcohol could cause long-term damage to the skin’s structure, making it more prone to wrinkles and sagging.

Now, Dr. Weiss works as an independent expert, writes books, and gives lectures worldwide.

He actively promotes the idea of using natural and safe ingredients in skincare.

Wrinkles: A worldwide problem that is underestimated

Wrinkles are not just a cosmetic blemish or an inevitable sign of aging.

They've become a global problem that affects self-esteem, psychological health, and even the economy.

Here's why wrinkles are more than just ‘creases in the skin’:

1. The extent of the problem

Prevalence: 90% of people over the age of 30 have wrinkles, and the number and depth of wrinkles increase with age.

Not Just Older People: More and more wrinkles are appearing in younger people due to stress, improper skin care and environmental factors.

Gender differences: Women are more likely to pay attention to wrinkles and spend more on wrinkles, but men also face this problem.

2. Causes of wrinkles: It's more complicated than it sounds

Wrinkles are the result of a combination of internal and external factors:

Natural aging: As we age, the skin loses collagen and elastin, causing it to lose its elasticity.

Photo-aging: Ultraviolet rays break down collagen fibres, accelerating the appearance of wrinkles.

Lifestyle:

Smoking: Nicotine constricts blood vessels, impairing skin nutrition.

Alcohol: Dehydrates the skin, making it more prone to wrinkles.

Stress: Increases the production of cortisol, which breaks down collagen.

Nutrition: Lack of vitamins, antioxidants and fatty acids accelerates skin aging.

Environmental: Air pollution and toxins contribute to the formation of free radicals that damage skin cells.

3. Consequences of wrinkles: Not just appearance

Wrinkles are not just an aesthetic problem.

They can have serious health and quality of life consequences:

Psychological consequences:

Low self-esteem: Many people feel less attractive because of wrinkles.

Depression and anxiety: Fear of aging and loss of youth can lead to emotional distress.

Social isolation: Some people avoid socialising because of insecurity about their appearance.

Physical effects:

Dry and thinning skin: Wrinkles are often accompanied by a decline in overall skin health.

Increased sensitivity: Aging skin is more prone to irritation and damage.

4. Economic consequences

Wrinkles are not only a personal problem but also an economic one:

Costs of care: People spend billions of dollars each year on creams, serums, Botox injections, fillers and other procedures.

Beauty Industry: The market for anti-ageing products is growing every year, reaching hundreds of billions of dollars.

Loss of productivity: People concerned about their appearance may waste time and resources searching for the ‘perfect’ solution.

5. Why is this a worldwide problem?



Culture of youth: Modern society puts youth and beauty first, which creates pressure on people of all ages.

Increased demand for anti-ageing products: People are willing to pay huge sums of money for products that promise ‘eternal youth’.

Lack of awareness: Many people do not know how to take proper care of their skin to prevent premature aging.

Wrinkles are not just ‘creases in the skin’. It is a global problem that affects the physical, emotional and social well-being of millions of people. Understanding the causes and effects of this problem is the first step to changing attitudes towards ageing and helping people feel confident at any age.

IGF-1 deficiency: An unexpected cause of wrinkles

When we talk about wrinkles, the factors most often discussed are aging, UV radiation, and collagen loss.

However, few people know that a lack of IGF-1 (insulin-like growth factor-1) can also play a key role in wrinkle formation.

This hormone, which is commonly associated with tissue growth and repair, has a significant impact on skin health.

Here's how it works:

What is IGF-1?

IGF-1 is a hormone that is produced in the liver under the influence of growth hormone (somatotropin). It plays an important role in:

Cell growth and division.

Collagen and elastin synthesis.

Repair and renewal of tissues, including skin.

How does IGF-1 deficiency affect the skin?

Decreased collagen synthesis:

Collagen is a protein that is responsible for the firmness and elasticity of the skin. IGF-1 stimulates its production. When this hormone is deficient, collagen synthesis decreases, resulting in thinning skin and wrinkles.

Slowdown of skin cell renewal:

IGF-1 promotes the division and renewal of skin cells. Its deficiency slows down this process, leading to the accumulation of old, damaged cells and deterioration of skin texture.

Deterioration of healing:

IGF-1 plays a key role in tissue repair. When it is deficient, the skin becomes more vulnerable to damage and the healing process slows down. This can lead to wrinkles and other signs of aging.

Loss of elasticity:

Elastin is another important protein that keeps skin firm. IGF-1 regulates its production, and when there is a deficiency of this hormone, the skin loses its ability to ‘spring back,’ which contributes to wrinkles.

Why does IGF-1 deficiency occur?

Age: IGF-1 levels naturally decline with age, which is one of the causes of skin aging.

Genetic factors: Some people have a congenital tendency to have low IGF-1 levels.

Chronic diseases: Liver, kidney or thyroid disease can impair IGF-1 production.

Improper diet: Deficiencies in protein, zinc, or vitamin D can reduce IGF-1 levels.

Stress and sleep deprivation: Chronic stress and lack of sleep suppress growth hormone production, which in turn reduces IGF-1 levels.

IGF-1 deficiency is an unexpected but important cause of wrinkles that is often overlooked. This hormone plays a key role in maintaining healthy skin, and a deficiency can lead to reduced collagen synthesis, slower cell renewal, and poor skin elasticity. Restoring IGF-1 balance through proper diet, exercise, and a healthy lifestyle can be an important step in fighting wrinkles and keeping skin looking youthful.

History of discovery: Rhodiola rosea and its rejuvenating secret.

In the early 2020s, a group of German scientists from the Institute for Biomedical Research in Berlin began a large-scale study to find natural remedies to combat skin ageing.

The project was led by Dr Martin Schulz, a renowned specialist in dermatology and endocrinology. His team focused on studying adaptogens - plants that help the body cope with stress and restore balance.

The research began

The idea to study Rhodiola rosea came about after Dr Schultz read about its use in traditional medicine in Siberia and Tibet.

Locals have used the plant for centuries to increase stamina, fight fatigue and improve general health. Scientists decided to test whether rhodiola could also influence the skin ageing process.

First experiments

The team started with laboratory studies on cell cultures.

They found that Rhodiola rosea extract:

Stimulates collagen and elastin production.

Reduces inflammation in skin cells.

Protects cells from oxidative stress.

These results inspired scientists to further explore the mechanisms of action of rhodiola.

Discovery of a link to IGF-1

In further studies, scientists looked at levels of IGF-1 (insulin-like growth factor-1), a key hormone that regulates tissue growth and repair. They found that Rhodiola rosea:

Reduces cortisol: Cortisol suppresses the production of growth hormone, which is necessary for IGF-1 synthesis.

Rhodiola, by reducing stress, indirectly increases IGF-1 levels.

Stimulates the pituitary gland: Rhodiola improves pituitary function, which leads to increased production of growth hormone and consequently IGF-1.

Improves cellular metabolism: Rhodiola increases energy metabolism in cells, which promotes better absorption of IGF-1 by tissues.

Clinical trials

Following successful laboratory experiments, Dr Schultz's team conducted clinical trials involving 100 volunteers between the ages of 40 and 60. The participants took Rhodiola rosea extract for 12 weeks.

The results were impressive:

IGF-1 levels in the blood increased by an average of 20 per cent.

Participants noticed an improvement in skin elasticity and a reduction in wrinkle depth.

The skin became more moisturised and radiant.

Publication of results

In 2023, Dr Schultz's team published their findings in the prestigious scientific journal Journal of Dermatological Science.

Their study showed that Rhodiola rosea not only increases IGF-1 levels, but also helps fight wrinkles, improving the overall health of the skin.

World recognition

The German scientists' discovery has generated a lot of interest in the scientific community and the cosmetic industry.

Rhodiola rosea became a key ingredient in new anti-ageing products, and its extract began to be actively used in aesthetic medicine clinics.

The story of the German scientists' discovery is an example of how traditional medicine and modern science can work together to create innovative solutions. Rhodiola rosea, thanks to its ability to increase IGF-1 levels and fight wrinkles, has become a real breakthrough in the fight against skin ageing.

The mechanism of work of rhodiola rosea

Antioxidant action:

Rhodiola contains substances that neutralise free radicals, protecting cells from oxidative stress.

This is important for maintaining healthy skin and preventing skin aging.

Adaptogenic effect:

Rhodiola helps the body cope with stress by reducing cortisol (stress hormone) levels.

High cortisol levels suppress the production of growth hormone (somatotropin), which in turn stimulates the synthesis of IGF-1.

Growth hormone stimulation:

Rhodiola can indirectly increase growth hormone levels, which leads to increased IGF-1 production. This is due to its ability to improve the function of the pituitary gland (the gland that produces growth hormone).

Improved energy metabolism:

Rhodiola increases the level of ATP (adenosine triphosphate), the main source of energy in cells.

This improves the overall health of the body and promotes tissue regeneration, including the skin.

Anti-inflammatory action:

Rhodiola reduces levels of inflammatory cytokines, which helps reduce inflammation in the skin and improve skin health.

How does rhodiola rosea normalise IGF-1?



Reducing cortisol levels:

Cortisol suppresses the production of growth hormone, which is necessary for IGF-1 synthesis. Rhodiola, by reducing cortisol levels, helps to increase growth hormone levels and consequently IGF-1.

Stimulation of the pituitary gland:

Rhodiola improves the function of the pituitary gland, which is responsible for the production of growth hormone. This, in turn, stimulates the synthesis of IGF-1 in the liver.

Improved cellular metabolism:

Rhodiola increases energy metabolism in cells, which promotes better absorption and utilisation of IGF-1 by tissues, including the skin.

Protection against oxidative stress:

Oxidative stress can damage cells and reduce IGF-1 levels. Rhodiola's antioxidant properties protect cells and maintain normal IGF-1 levels.

Practical Uses of Rhodiola rosea

For the skin:

Rhodiola can improve collagen and elastin synthesis, which helps reduce wrinkles and improve skin elasticity.

For general health:

Rhodiola helps fight fatigue and improves physical and mental stamina, which indirectly supports IGF-1 levels.

For stress management:

By reducing cortisol levels, rhodiola helps to support the balance of hormones including IGF-1.

Rhodiola rosea is a powerful adaptogen that helps normalise IGF-1 levels through reducing stress, stimulating growth hormone and improving cellular metabolism. Its use can be beneficial for maintaining healthy skin, fighting aging, and improving overall body health.

GlowVeris uses a science-backed, six-step mechanism to rejuvenate your skin:

1. Cellular Activation: Retinol penetrates deep into the skin layers, stimulating collagen and elastin production.

2. Enhanced Hydration: Locks in moisture to plump the skin and reduce the appearance of wrinkles.

3. Improved Elasticity: Strengthens the skin barrier, making it firmer and more resilient.

4. Even Skin Tone: Reduces pigmentation, freckles, and dark spots for a luminous complexion.

5. Antioxidant Protection: Shields your skin from free radicals and environmental damage.

• 6. Long-Term Renewal: Maintains healthy cell turnover, ensuring lasting results.

What to Expect

Week 1-2

Skin adjustment period

Initial hydration benefits

Possible mild sensitivity

Week 3-4

Improved skin texture

Enhanced radiance

Reduced surface roughness

Week 8-12

Visible reduction in fine lines

More even skin tone

Increased firmness

Month 3 and Beyond

Continued improvement in skin texture

Long-term anti-aging benefits

Maintained results with consistent use

Proper Application

• Cleanse thoroughly
• Apply to dry skin
• Use appropriate amount
• Follow with moisturizer
• Apply sunscreen daily

Optimal Timing

• Use in evening routine
• Start 2-3 times weekly
• Increase gradually
• Be consistent

Skin Protection

• Use daily sun protection
• Avoid excessive sun exposure
• Maintain healthy skincare routine
• Stay hydrated

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